SUMMARY:-Thyroid function tests (TFT) is a collective term for blood tests used to check the function of the thyroid.TFT may be requested if a patient is thought to suffer from hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid), or to monitor the effectiveness of either thyroid-suppression or hormone replacement therapy. It is also requested routinely in conditions linked to thyroid disease, such as atrial fibrillation and anxiety disorder.A TFT panel typically includes thyroid hormones such as thyroidstimulating hormone (TSH, thyrotropin) and thyroxine (T4), andtriiodothyronine (T3) depending on local laboratory policy. Normal changes in thyroid function tests during pregnancy,total T4 and T3 steadily increase during pregnancy.The thyroid gland is normally regulated by thyroid-stimulating hormone (TSH), also called thyrotropin, which is secreted by the pituitary. TSH stimulates the thyroid gland to produce and release the thyroid hormones thyroxine (T4) and triiodothyronine (T3) . T4 and T3 are released from the thyroid into the bloodstream,Increased levels of free thyroid hormones (T4 and T3) inhibit TSH secretion from the pituitary, whereas decreased levels of T4 and T3 cause an increase in TSH release from the pituitary. Hyperthyroidism( LowTSH level) may include: Increased heart rate, Anxiety, Weight loss, Difficulty sleeping, Tremors in the hands, Weakness, Diarrhea (sometimes), Light sensitivity, visual disturbances,The eyes may be affected: puffiness around the eyes, dryness, irritation, and, in some cases, bulging of the eyes. Hypothyroidism(High TSH level) may include: Weight gain, Dry skin, Constipation, Cold intolerance, Puffy skin, Hair loss, Fatigue, Menstrual irregularity in women.TSH may be ordered at regular intervals when an individual is being treated for a known thyroid disorder. When a persons dose of thyroid medication is adjusted, it is recommends waitinig 6-8 weeks before testing the level of TSH again.TSH decreases when fasting. Most patients do their lab tests in a fasting state, because other labs like glucose and cholesterol require it. But this may result in an artificially low TSH that does not reflect true thyroid levels. In fact, TSH has a circadian rhythm, with a peak around midnight (with much variability between individuals), and a low in the afternoon; fluctuations are normal. The change in TSH from peak to trough is approximately 72%.
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